The incidence of treatment-emergent adverse events has been ascertained from clinical trials conducted worldwide. All adverse events reported during these trials were recorded as adverse reactions. The incidence rates presented below are based on combined data from six placebo-controlled trials involving once-a-day administration of Terazosin at doses ranging from 1 to 20 mg. Table 1 summarizes those adverse events reported for patients in these trials when the incidence rate in the Terazosin group was at least 1%, and was greater than that for the placebo group, or where the reaction is of clinical interest. buy generic phenazopyridine pharmacy australia
Our Hytrin terazosin hydrochloride Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. Iloprost: The effects of iloprost on blood pressure may be additive to those of antihypertensive agents. Lower doses of the antihypertensive may be needed with combined treatment. Halothane: General anesthetics can potentiate the hypotensive effects of antihypertensive agents.
Carbetapentane; Chlorpheniramine; Phenylephrine: Sympathomimetics can antagonize the effects of antihypertensives such as alpha-blockers when administered concomitantly. In hemodynamic studies, Tikosyn had no effect on cardiac output, cardiac index, stroke volume index, or systemic vascular resistance in patients with ventricular tachycardia, mild to moderate congestive heart failure or angina, and either normal or low left ventricular ejection fraction. There was no evidence of a negative inotropic effect related to Tikosyn therapy in patients with atrial fibrillation. There was no increase in heart failure in patients with significant left ventricular dysfunction see . In the overall clinical program, Tikosyn did not affect blood pressure.
Ethinyl Estradiol; Levonorgestrel: Estrogen-containing oral contraceptive may induce fluid retention and may increase blood pressure in some patients taking antihypertensive agents. Such patients should be monitored to confirm that the desired antihypertensive effect is being obtained. General anesthetics: General anesthetics can potentiate the hypotensive effects of antihypertensive agents. This medication passes into breast milk. Consult your doctor before breast-feeding.
QD was co-administered with Tikosyn 500 mcg BID for 5 days following 2 days of diuretic use at half dose. In patients receiving HCTZ alone, dofetilide AUC increased by 27% and C max by 21%. However, the pharmacodynamic effect increased by 197% QTc increase over time and by 95% maximum QTc increase. In patients receiving HCTZ in combination with triamterene, dofetilide AUC increased by 30% and C max by 16%. However, the pharmacodynamic effect increased by 190% QTc increase over time and by 84% maximum QTc increase. The pharmacodynamic effects can be explained by a combination of the increase in dofetilide exposure and the reductions in serum potassium. In the DIAMOND trials, 1252 patients were treated with Tikosyn and diuretics concomitantly, of whom 493 died compared to 508 deaths among the 1248 patients receiving placebo and diuretics. Food and Drug Administration. WebMD does not endorse any specific product, service, or treatment. Do not consider WebMD User-generated content as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource, but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately. This lesion has also been seen with prazosin hydrochloride, another marketed selective-alpha-1 blocking agent. If you miss your doses for several days in a row, contact your doctor before restarting the medication. You may need a lower dose. Excreted in urine 40% and in feces 60%. Tikosyn can cause serious side effects, including a type of abnormal heartbeat called Torsade de Pointes, which can lead to death. See "What is the most important information I should know about Tikosyn?
Dahlof B, Devereux RB, Kjeldsen SE, et al. Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint Reduction in Hypertension Study LIFE. Lancet. WebMD User Reviews should not be considered as medical advice and are not a substitute for professional medical advice, diagnosis, or treatment. Never delay or disregard seeking professional medical advice from your physician or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences may be a helpful health information resource but they are never a substitute for professional medical advice from a qualified healthcare provider. Terazosin helps to lower blood pressure by relaxing blood vessels so that blood passes through them more easily. Every effort has been made to ensure that the information provided by Cerner Multum, Inc. 'Multum' is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. American Urological Association Practice Guideline Committee. AUA guidelines on management of benign prostatic hyperplasia 2003. Chapter 1: Diagnosis and treatment recommendations. J Urol. Fish Oil, Omega-3 Fatty Acids Dietary Supplements: Co-enzyme Q10, ubiquinone CoQ10 may lower blood pressure. CoQ10 use in combination with antihypertensive agents may lead to additional reductions in blood pressure in some individuals. Patients who choose to take CoQ10 concurrently with antihypertensive medications should receive periodic blood pressure monitoring. Patients should be advised to inform their prescriber of their use of CoQ10. Terazosin can affect your pupils during cataract surgery. Tell your eye surgeon ahead of time that you are using this medication. Rarely, probably less than once in every several thousand patients Terazosin and other α 1-antagonists have been associated with priapism painful penile erection, sustained for hours and unrelieved by sexual intercourse or masturbation. Two or three dozen cases have been reported. Tetracaine: Local anesthetics may cause additive hypotension in combination with antihypertensive agents. Use extreme caution with the concomitant use of tetracaine and antihypertensive agents. Go AS, Bauman MA, Coleman King SM et al. An effective approach to high blood pressure control: a science advisory from the American Heart Association, the American College of Cardiology, and the Centers for Disease Control and Prevention. Hypertension. Methylphenidate: Sympathomimetics can antagonize the effects of antihypertensives such as alpha-blockers when administered concomitantly. Terazosin than in patients receiving placebo. Similar adverse reaction rates were observed in placebo-controlled monotherapy trials. Tikosyn and placebo for 551 and 207 patient years, respectively. Deger G. Comparison of the safety and efficacy of once- daily terazosin versus twice-daily prazosin for the treatment of mild to moderate hypertension. Am J Med. The ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial ALLHAT. JAMA. indomethacin
Carefully monitor BP during initial titration or subsequent upward dosage adjustment. Hernandez RH, Angeligreaves M, Carvajal AR, Pajuelo JG, Padilla MCA, Armashernandez MJ "Terazosin: ex vivo and in vitro platelet aggregation effects in patients with arterial hypertension. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company. Of the 506 patients in the DIAMOND studies who had atrial fibrillation or flutter at baseline, 12% of patients in the Tikosyn group and 2% of patients in the placebo group had converted to normal sinus rhythm after one month. In those patients converted to normal sinus rhythm, 79% of the Tikosyn group and 42% of the placebo group remained in normal sinus rhythm for one year. Carbinoxamine; Phenylephrine: Sympathomimetics can antagonize the effects of antihypertensives such as alpha-blockers when administered concomitantly. Before initiating Tikosyn therapy, previous antiarrhythmic therapy should be withdrawn under careful monitoring for a minimum of three 3 plasma half-lives. cheap alternatives to armidex armidex
Your pharmacist can provide more information about terazosin. Chlorpheniramine; Dextromethorphan; Phenylephrine: Sympathomimetics can antagonize the effects of antihypertensives such as alpha-blockers when administered concomitantly. Tikosyn can be taken with or without food. Your doctor has prescribed Terazosin capsules for your BPH and not for prostate cancer. However, a man can have BPH and prostate cancer at the same time. Doctors usually recommend that men be checked for prostate cancer once a year when they turn 50 or 40 if a family member has had prostate cancer. These checks should continue even if you are taking Terazosin capsules. Terazosin capsules are not a treatment for prostate cancer. Doses of 10 mg once daily are generally required for the clinical response. Therefore, treatment with 10 mg for a minimum of 4 to 6 weeks may be required to assess whether a beneficial response has been achieved. Some patients may not achieve a clinical response despite appropriate titration. Although some additional patients responded at a 20 mg daily dose, there was an insufficient number of patients studied to draw definitive conclusions about this dose. There are insufficient data to support the use of higher doses for those patients who show inadequate or no response to 20 mg daily. If Terazosin administration is discontinued for several days or longer, therapy should be reinstituted using the initial dosing regimen. Ex-Lax, Feen-a-Mint, or speed up how fast a stool moves through the intestines by irritating the lining of the intestines. Regular use of stimulant laxatives is not recommended. Stimulant laxatives change the tone and feeling in the large intestine and you can become dependent on using laxatives all the time to have a bowel movement. NSR for the 12 months duration of the studies. Kirby RS. Alpha-adrenoceptor inhibitors in the treatment of benign prostatic hyperplasia. Am J Med. It is not known if Tikosyn passes into your breast milk. You and your doctor should decide if you will take Tikosyn or breast-feed. You should not do both. buy spiriva quebec
Carbetapentane; Phenylephrine; Pyrilamine: Sympathomimetics can antagonize the effects of antihypertensives such as alpha-blockers when administered concomitantly. Rapidly and almost completely absorbed from the GI tract following oral administration. 1 2 Peak plasma concentration attained in about 1 hour. This information should not be used to decide whether or not to take terazosin or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about terazosin. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to terazosin. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using terazosin. Phendimetrazine: Sympathomimetics can antagonize the effects of antihypertensives such as alpha-blockers when administered concomitantly. Please refer patient to the Medication Guide. Symptoms may include dizziness; weakness. Terazosin is used to treat hypertension high blood pressure or to improve urination in men with benign prostatic hyperplasia enlarged prostate. Conivaptan: There is potential for additive hypotensive effects when conivaptan is coadministered with antihypertensive agents. Luther RR, Glassman HN, Estep CB et al. The effects of terazosin and methyclothiazide on blood pressure and serum lipids. PROGRESS Collaborative Group. Randomised trial of a perindopril-based blood-pressure-lowering regimen among 6105 individuals with previous stroke or transient ischaemic attack. Lancet.
What is the most important information I should know about Tikosyn? There are many other ways to treat constipation, such as drinking more water or adding more fiber, fruits, and vegetables to your diet. These are often recommended in addition to taking laxatives. Tikosyn dofetilide can cause serious ventricular arrhythmias, primarily Torsade de Pointes TdP type ventricular tachycardia, a polymorphic ventricular tachycardia associated with QT interval prolongation. QT interval prolongation is directly related to dofetilide plasma concentration. Factors such as reduced creatinine clearance or certain dofetilide drug interactions will increase dofetilide plasma concentration. The risk of TdP can be reduced by controlling the plasma concentration through adjustment of the initial dofetilide dose according to creatinine clearance and by monitoring the ECG for excessive increases in the QT interval. Tikosyn than placebo in patients with supraventricular arrhythmias: angioedema, bradycardia, cerebral ischemia, cerebrovascular accident, edema, facial paralysis, flaccid paralysis, heart arrest, increased cough, liver damage, migraine, myocardial infarct, paralysis, paresthesia, sudden death, and syncope. Concomitant use of verapamil is contraindicated. Co-administration of Tikosyn with verapamil resulted in increases in dofetilide peak plasma levels of 42%, although overall exposure to dofetilide was not significantly increased. In an analysis of the supraventricular arrhythmia and DIAMOND patient populations, the concomitant administration of verapamil with dofetilide was associated with a higher occurrence of Torsade de Pointes. It is possible that some side effects of terazosin may not have been reported. It is not known whether terazosin passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Tikosyn. The majority of cases 76% occurred within the first 3 days of dosing. At first, 1 milligram mg taken at bedtime. Then, 5 to 10 mg once a day. Iloperidone: Secondary to alpha-blockade, iloperidone can produce vasodilation that may result in additive effects during concurrent use with antihypertensive agents. The potential reduction in blood pressure can precipitate orthostatic hypotension and associated dizziness, tachycardia, and syncope. If concurrent use of iloperidone and antihypertensive agents is necessary, patients should be counseled on measures to prevent orthostatic hypotension, such as sitting on the edge of the bed for several minutes prior to standing in the morning and rising slowly from a seated position. Close monitoring of blood pressure is recommended until the full effects of the combination therapy are known. Guaifenesin; Pseudoephedrine: The cardiovascular effects of pseudoephedrine may reduce the antihypertensive effects produced by alpha-blockers. Monitor blood pressure and heart rate. cheapest flagyl australia
Ethinyl Estradiol; Norethindrone; Ferrous fumarate: Estrogen-containing oral contraceptive may induce fluid retention and may increase blood pressure in some patients taking antihypertensive agents. Such patients should be monitored to confirm that the desired antihypertensive effect is being obtained. As shown, both the probability of a patient's remaining in sinus rhythm at six months and the change in QTc from baseline at steady state of dosing increased in an approximately linear fashion with increasing dose of Tikosyn. Note that in these studies, doses were modified by results of creatinine clearance measurement and in-hospital QTc prolongation. Terazosin is also used in men to treat the symptoms of an enlarged prostate benign prostatic hyperplasia-BPH. It does not shrink the prostate, but it works by relaxing the muscles in the prostate and part of the bladder. This helps to relieve symptoms of BPH such as difficulty in beginning the flow of urine, weak stream, and the need to urinate frequently or urgently including during the middle of the night. You should not use this medication if you are allergic to terazosin. Hypersensitivity reactions have been reported, including anaphylaxis and rashes. Ask your doctor if you are not sure if any of your medicines are the kind listed above. Some medical conditions may interact with terazosin. Phentermine; Topiramate: Sympathomimetics can antagonize the effects of antihypertensives such as alpha-blockers when administered concomitantly. Ethinyl Estradiol; Norethindrone: Estrogen-containing oral contraceptive may induce fluid retention and may increase blood pressure in some patients taking antihypertensive agents. Such patients should be monitored to confirm that the desired antihypertensive effect is being obtained. Articaine; Epinephrine: Sympathomimetics, such as epinephrine, can antagonize the effects of alpha-blockers when administered concomitantly. Patients receiving alpha-blockers can exhibit a decreased pressor response to epinephrine, resulting in an increased risk of developing hypotension and tachycardia. Blood pressure should be monitored closely. OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional. Diphenhydramine; Phenylephrine: Sympathomimetics can antagonize the effects of antihypertensives such as alpha-blockers when administered concomitantly. Tranylcypromine: The use of hypotensive agents and tranylcypromine is contraindicated by the manufacturer of tranylcypromine because the effects of hypotensive agents may be markedly potentiated. Hypokalemia or hypomagnesemia may occur with administration of potassium-depleting diuretics, increasing the potential for Torsade de Pointes. Peripheral alpha 1-adrenergic receptor blocking agents aka alpha 1-blockers cause vasodilation and can produce marked hypotension, especially orthostatic hypotension with syncope or other postural symptoms such as dizziness, lightheadedness, and palpitations. Orthostatic effects are most common during initiation of therapy and often occur within 90 minutes after the first dose. However, they can also occur following a dosage increase or resumption of therapy after an interruption of more than a few days. Agents with alpha 1a specificity, such as tamsulosin, act primarily on the prostate but are not devoid of hypotensive effects. Therapy with peripheral alpha-1 blockers should be administered cautiously in patients with or predisposed to hypotensive or syncopal episodes. Ritodrine: Sympathomimetics can antagonize the effects of antihypertensives such as alpha-blockers when administered concomitantly. is there generic periactin yet periactin
Associated Press American Diabetes Association. Diabetics urged: drop blood pressure. Chicago, IL; 2000 Aug 29. Press Release from web site. The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables. Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine: The cardiovascular effects of pseudoephedrine may reduce the antihypertensive effects produced by alpha-blockers. Monitor blood pressure and heart rate. To establish the right dose of Tikosyn, treatment with Tikosyn must be started in a hospital where your heart rate and kidney function will be checked for the first 3 days of treatment. It is important that when you go home, you take the exact dose of Tikosyn that your doctor prescribed for you. Although drug therapy usually is not as effective as surgical therapy, it may provide adequate symptomatic relief with fewer and less serious adverse effects compared with surgery. Garraway WM, Collins GN, Lee RJ. High prevalence of benign prostatic hypertrophy in the community. Lancet. Bromocriptine: Bromocriptine has only minimal affinity for adrenergic receptors; however, hypotension can occur during bromocriptine administration. Orthostatic hypotension occurs in 6% of acromegaly patients receiving the drug. Hypotension occurred frequently approximately 30% in postpartum studies, which in rare cases approached a decline in supine pressure of almost 60 mmHg. It is unknown if bromocriptine is the exact cause of this effect. However, the drug should be used cautiously with other medications known to lower blood pressure such as antihypertensive agents. Monitoring of blood pressure should be considered, especially during the initial weeks of concomitant therapy. Cardiovascular side effects have included orthostatic hypotension, which generally occurs within 30 to 60 minutes after the first dose. For this reason, it is recommended that the first dose be administered at bedtime. Other symptoms of hypotension, such as mild to moderate dizziness, lightheadedness, palpitations and weakness have occurred in 1% to 30% of patients. Some cardiovascular side effects, particularly dizziness, have been more prevalent among persons greater than 65 years old. Pull the plastic completely apart at the notched end. In the treatment of benign prostatic hypertrophy, terazosin blocks alpha1-adrenergic receptors present in the smooth muscle of the bladder neck and prostate, allowing the bladder neck and the prostate to relax. This causes less pressure on the urethra and increases urine flow. Terazosin appears to be more effective than finasteride Proscar for relieving symptoms associated with BPH. desvenlafaxine
Remember that terazosin will not cure your high blood pressure but it does help control it. Therefore, you must continue to take it as directed if you expect to lower your blood pressure and keep it down. The dosing algorithm shown above should be used to determine the individualized dose of Tikosyn. In clinical trials see the highest dose of 500 mcg BID of Tikosyn as modified by the dosing algorithm led to greater effectiveness than lower doses of 125 or 250 mcg BID as modified by the dosing algorithm. The risk of Torsade de Pointes, however, is related to dose as well as to patient characteristics see . Physicians, in consultation with their patients, may therefore in some cases choose doses lower than determined by the algorithm. It is critically important that if at any time this lower dose is increased, the patient needs to be rehospitalized for three days. Previous toleration of higher doses does not eliminate the need for rehospitalization. Importance of advising patients of other important precautionary information. 1 See Cautions. Dobutamine: Sympathomimetics can antagonize the effects of antihypertensives such as alpha-blockers when administered concomitantly. If a child is using this medication, a parent or other responsible adult should supervise and help the child use this medication properly. Read the Patient Information Leaflet if available from your pharmacist before you start taking terazosin and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Phenylephrine: Sympathomimetics can antagonize the effects of antihypertensives such as alpha-blockers when administered concomitantly.
Keep out of the reach of children. Some things can cause your blood pressure to get too low. This includes vomiting, diarrhea, heavy sweating, heart disease, dialysis, a low-salt diet, or taking diuretics water pills. Tell your doctor if you have a prolonged illness that causes diarrhea or vomiting. Lepor H. The emerging role of alpha antagonists in the therapy of benign prostatic hyperplasia. J Androl. If you are taking this drug for the first time, do not take more than 1 milligram to start. Terazosin may cause a sudden drop in your blood pressure, which could lead to dizziness or fainting. This risk is higher when taking your first dose. Therefore, to avoid injury related to dizziness or fainting, take your first dose of terazosin at bedtime. Renal function and QTc should be re-evaluated every three months or as medically warranted. If QTc exceeds 500 milliseconds 550 msec in patients with ventricular conduction abnormalities Tikosyn therapy should be discontinued and patients should be carefully monitored until QTc returns to baseline levels. Dizziness, lightheadedness, or sudden fainting may occur after you take terazosin, especially when you get up from a lying or sitting position. These effects are more likely to occur when you take the first dose of terazosin. Taking the first dose at bedtime may prevent problems. However, be especially careful if you need to get up during the night. These effects may also occur with any doses you take after the first dose. Getting up slowly may help lessen this problem. If you feel dizzy, lie down so that you do not faint. Then sit for a few moments before standing to prevent the dizziness from returning. Some experts state that an α 1-blocker may be a useful component of antihypertensive treatment regimens in older men with coexisting benign prostatic hyperplasia BPH; 504 however, the American Urology Association AUA states that monotherapy with these drugs is not optimal in hypertensive patients with lower urinary tract symptoms LUTS or BPH and that such conditions should be managed separately. It is not known whether Terazosin is excreted in breast milk. Because many drugs are excreted in breast milk, caution should be exercised when Terazosin capsules are administered to a nursing woman. At first, 1 mg taken at bedtime. Then, 1 to 5 mg once a day. generic clavamox online low price
Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine: The cardiovascular effects of pseudoephedrine may reduce the antihypertensive effects produced by alpha-blockers. Monitor blood pressure and heart rate. Dizziness, lightheadedness, or fainting especially when getting up from a lying or sitting position may be more likely to occur in the elderly, who are more sensitive to the effects of terazosin. Program of monitoring or “Watchful Waiting”. Some men have an enlarged prostate gland, but no symptoms, or symptoms that are not bothersome. If this applies, you and your doctor may decide on a program of monitoring including regular checkups, instead of medication or surgery. Hosmane BS, Maurath CJ, Jordan DC, Laddu A "Effect of age and dose on the incidence of adverse events in the treatment of hypertension in patients receiving terazosin. The prevalence of adverse reactions has been ascertained from clinical trials conducted primarily in the United States. All adverse experiences events reported during these trials were recorded as adverse reactions. The prevalence rates presented below are based on combined data from fourteen placebo-controlled trials involving once-a-day administration of Terazosin, as monotherapy or in combination with other antihypertensive agents, at doses ranging from 1 to 40 mg. Table 3 summarizes those adverse experiences reported for patients in these trials where the prevalence rate in the Terazosin group was at least 5%, where the prevalence rate for the Terazosin group was at least 2% and was greater than the prevalence rate for the placebo group, or where the reaction is of particular interest. Tikosyn dofetilide increases the monophasic action potential duration in a predictable, concentration-dependent manner, primarily due to delayed repolarization. This effect, and the related increase in effective refractory period, is observed in the atria and ventricles in both resting and paced electrophysiology studies. The increase in QT interval observed on the surface ECG is a result of prolongation of both effective and functional refractory periods in the His-Purkinje system and the ventricles. Do not rinse the dropper. Replace the dropper cap after each use. Brompheniramine; Hydrocodone; Pseudoephedrine: The cardiovascular effects of pseudoephedrine may reduce the antihypertensive effects produced by alpha-blockers. Monitor blood pressure and heart rate. Know the medicines you take. Keep a list of your medicines and show it to your doctor and pharmacist when you get a new medicine. Follow the instructions on how to properly prime the bottle if you are using it for the first time or if you have not used it for a week or more. Spray this medication in the nose, usually 1 to 3 times a day as directed by your doctor. If the dose is more than 1 spray, spray half the dose in each nostril. For example, if the dose is 2 sprays, give 1 spray in each nostril. Terazosin capsules are contraindicated in patients known to be hypersensitive to Terazosin hydrochloride. alugo.info elimite
Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Truven Health does not assume any responsibility or risk for your use of the Truven Health products. Most reports were in patients treated with an alpha-1 blocker at the time IFIS occurred, but in some instances the alpha-1 blocker had been stopped prior to surgery. The manufacturer recommends that patients be questioned to determine whether or not they have taken alpha-1 blockers prior to being considered for cataract surgery. If it is determined that the patient has taken an alpha-1 blocker, the patient's ophthalmologist should be prepared for possible modifications to their surgical technique that may be necessary should IFIS be observed during the procedure. Additional adverse reactions have been reported, but these are, in general, not distinguishable from symptoms that might have occurred in the absence of exposure to terazosin. It has also been used to help treat bladder problems in women. Terazosin hydrochloride works by relaxing blood vessels so that blood passes through them more easily. This helps to lower blood pressure. Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Increased fetal resorptions, decreased fetal weight and an increased number of supernumerary ribs were observed in offspring of rabbits dosed with 60 times the maximum recommended human dose. These findings in both species were most likely secondary to maternal toxicity. There are no adequate and well-controlled studies in pregnant women and the safety of Terazosin in pregnancy has not been established. Terazosin capsules are not recommended during pregnancy unless the potential benefit justifies the potential risk to the mother and fetus. Testicular weights and morphology were unaffected by treatment. quibron
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Terazosin is in a group of drugs called alpha-adrenergic AL-fa ad-ren-ER-jik blockers. Terazosin relaxes your veins and arteries so that blood can more easily pass through them. It also relaxes the muscles in the prostate and bladder neck, making it easier to urinate. Pentoxifylline: Pentoxifylline has been used concurrently with antihypertensive drugs beta blockers, diuretics without observed problems. Small decreases in blood pressure have been observed in some patients treated with pentoxifylline; periodic systemic blood pressure monitoring is recommended for patients receiving concomitant antihypertensives. If indicated, dosage of the antihypertensive agents should be reduced.
Elhilali MM, Ramsey EW, Barkin J, Casey RW, Boake RC, Beland G, Fradet Y, Trachtenberg J, Orovan WL, Schick E, Klotz LH "A multicenter, randomized, double-blind, placebo-controlled study to evaluate the safety and efficacy of terazosin in the treatment of benign prostatic hyperplasia. Ethinyl Estradiol; Norgestimate: Estrogen-containing oral contraceptive may induce fluid retention and may increase blood pressure in some patients taking antihypertensive agents. Such patients should be monitored to confirm that the desired antihypertensive effect is being obtained. Thiothixene: Thiothixene should be used cautiously in patients receiving antihypertensive agents. Additive hypotensive effects are possible.
Chlorpheniramine; Hydrocodone; Phenylephrine: Sympathomimetics can antagonize the effects of antihypertensives such as alpha-blockers when administered concomitantly. Alprostadil: The concomitant use of systemic alprostadil injection and antihypertensive agents, such as terazosin, may cause additive hypotension. Caution is advised with this combination. Systemic drug interactions with the urethral suppository MUSE or alprostadil intracavernous injection are unlikely in most patients because low or undetectable amounts of the drug are found in the peripheral venous circulation following administration. In those men with significant corpora cavernosa venous leakage, hypotension might be more likely. Use caution with in-clinic dosing for erectile dysfunction ED and monitor for the effects on blood pressure. In addition, the presence of medications in the circulation that attenuate erectile function may influence the response to alprostadil. However, in clinical trials with alprostadil intracavernous injection, anti-hypertensive agents had no apparent effect on the safety and efficacy of alprostadil.
Dose reductions for reduced calculated creatinine clearance occurred in 47% and 45% of DIAMOND CHF and MI patients, respectively. Dose reductions for increased QT interval or QTc occurred in 5% and 7% of DIAMOND CHF and MI patients, respectively. Some products that may interact with this drug include: other alpha blocker drugs such as prazosin, tamsulosin. Sevoflurane: General anesthetics can potentiate the hypotensive effects of antihypertensive agents.